Table 2 Diagnostic accuracy of the MTB antigen-stimulated INF-γ and IL-2 for diagnosis of active tuberculosis
Cytokine | AUC (95% CI) | Cut-off value (pg/mL) | Sensitivity (%, 95% CI) | Specificity (%, 95% CI) | PPV (%, 95% CI) | NPV (%, 95% CI) |
|---|---|---|---|---|---|---|
IFN-γ | 0.859 (0.842–0.875) | 7.38 | 83.8 (82.2–85.2) | 81.5 (78.4–84.2) | 94.1 (93.0–95.0) | 58.7 (55.5–61.7) |
IL-2 | 0.865 (0.851–0.879) | 20.19 | 72.6 (70.8–74.3) | 94.3 (92.3–95.8) | 97.8 (97.0–98.4) | 49.3 (46.6–52.0) |