From: Chronic obstructive pulmonary disease does not impair responses to resistance training
Comparison | Gene set | Significance category* | Set size†| Rank P-value‡ | % MSD > 0§ | GSEA P-value|| | NES | LE** | Log2 fold difference in LE (95% CI) |
---|---|---|---|---|---|---|---|---|---|
Baseline: COPD vs Healthy | Oxidative phosphorylation | Consensus | 190 (200) | 0.007 | 36.8% |  < 0.001 | − 2.10 | 70 (94.3%) | − 0.24 (− 0.45, − 0.13) |
Myogenesis | Rank | 163 (200) |  < 0.001 | 33.7% | 0.417 | 1.21 | 45 (75.6%) | 0.46 (0.19, 1.5) | |
3½ weeks of training: ΔCOPD vs ΔHealthy | Allograft rejection | GSEA | 115 (200) | 0.956 | 7.8% | 0.014 | 1.71 | 20 (35%) | 0.39 (0.13, 0.76) |
Oxidative phosphorylation | GSEA | 190 (200) | 0.999 | 1.1% | 0.009 | 1.69 | 83 (2.4%) | 0.11 (0.05, 0.39) | |
Pancreas beta cells | GSEA | 15 (40) | 0.969 | 6.7% | 0.028 | 1.71 | 3 (33.3%) | 0.35 (0.08, 0.54) | |
Post− RT (13 weeks of training): ΔCOPD vs ΔHealthy | Myogenesis | Consensus | 163 (200) |  < 0.001 | 42.3% |  < 0.001 | − 1.52 | 68 (85.3%) | − 0.5 (− 1.13, − 0.26) |