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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Chronic obstructive pulmonary disease does not impair responses to resistance training

Fig. 7

Comparisons of the effects of the resistance training intervention on changes in myonuclei per fiber and myonuclei domain in muscle fiber types I and II (A, B; COPD, n = 11; Healthy, n = 34), and on changes in muscle fiber type proportions in COPD and Healthy, measured using immunohistochemistry (CE; COPD, n = 17; Healthy, n = 51)) and qPCR (gene family profiling-normalized myosin heavy chain mRNA expression, FH; COPD, n = 19; Healthy, n = 55), as previously described [26, 75]. Myonuclei domain was calculated as mean fiber cross-sectional area divided by myonuclei per fiber. For myonuclei per fiber and myonuclei domain in muscle fiber types I and II, comparisons are presented as relative changes from baseline to after the training intervention (per study cluster; A) and as relative differences in change scores between study clusters (B). For muscle fiber type proportions, data are presented as adjusted values at baseline and after the training intervention (Post RT), and results are presented as the effect of the training intervention for the study clusters combined and its interaction with study clusters (CH). For myonuclei variables, no training-associated differences were observed between study clusters. Both COPD and Healthy displayed training-associated reductions in proportions of type IIX muscle fibers, measured using both immunohistochemistry and qPCR. Intriguingly, while this reduction was greater in COPD when measured at the protein level (immunohistochemistry), it was greater in Healthy when measured at the mRNA level (qPCR), indicating differentially regulated muscle fiber shifting in COPD and Healthy. Data are presented as means with 95% confidence limits

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