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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Chronic obstructive pulmonary disease does not impair responses to resistance training

Fig. 3

Whole-genome transcriptome analyses of m. vastus lateralis in COPD and Healthy (COPD, n = 19; Healthy, n = 34). At baseline, numerous genes were differentially expressed between COPD and Healthy. In A, differences in gene expression between COPD and Healthy are presented with leading edge genes (i.e. genes that contributes to the enrichment score) from two gene sets identified as differentially expressed between COPD and Healthy from gene enrichment analyses (oxidative phosphorylation and myogenesis; see Table 3). In B, average fold differences (COPD-Healthy) of genes contributing to baseline differences in oxidative phosphorylation and myogenesis gene sets are shown as individual data points, and violin plots shows the distribution of all leading edge genes from each gene set. C displays the average development of each gene set over time, where the dotted line indicates the mean fold change of all genes contributing to the differential change over time between COPD and Healthy. COPD displayed larger increases in expression of genes relating to oxidative phosphorylation after 3½ weeks of training, and more pronounced decreases in genes associated with myogenesis to after the training intervention (Post-RT; see Table 3). FDR, false discovery rate-adjusted p-value

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