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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease

Fig. 2

Genomic activation of the immunoproteasome in lung tissue of COVID-19 patients correlates with the amount of SARS-CoV-2 detected. A Geneset enrichment analysis demonstrating the relative expression of the genomic cluster of the immunoproteasome in lung samples with high levels of SARS-CoV-2 versus lung samples with low levels of SARS-CoV-2 (NES: normalized enrichment score; FDR: False Discovery Rate). B Unsupervised principal component analysis of expression profiles of immunoproteasome-associated genes, with clustering patterns reflecting the level of SARS-CoV-2 detected in the lung (Pearson p-value was estimated for group discrimination along the first principal axis). C Boxplots of immunoproteasome-related gene expression as a function of the level of SARS-CoV-2 detected in the lung (two sided ttest p-values between low and high groups). D Correlation plot illustrating the relationship between lung expression of different immunoproteasome-related genes in patients with COVID-19 (blue: positive correlation, red: negative correlation). E Location of immunoproteasome genes that demonstrated SARS-CoV-2–associated activation on chromosome 6 (HG38). All analyses were performed using transcriptome dataset GSE150316

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