Fig. 1

Activation of MHC class I antigen presentation in lung tissue of COVID-19 patients is associated with amount of SARS-CoV-2 present in the tissue. A Dot plot of SARS-COV2 lung quantification stratified on patients groups and medical centers (two sided ttest p-value for group stratification). B Geneset enrichment analysis demonstrating relative expression of MHC class I antigen processing and presentation machinery in lung samples with high levels of SARS-CoV-2 versus lung samples with low levels of SARS-CoV-2 (NES: normalized enrichment score, FDR: False Discovery Rate). C Unsupervised principal component analysis of expression profiles of genes associated with MHC class I antigen presentation, with clustering patterns reflecting the levels of SARS-CoV-2 detected in the lung (Pearson p-value was estimated for group discrimination along the first principal axis). D Functional network of genes implicated in the SARS-CoV-2–associated activation of MHC class I antigen presentation in lung tissue of COVID-19 patients. All analyses were performed using transcriptome dataset GSE150316