Skip to main content

Table 5 The diagnostic accuracy of WT1 mRNA and 1/ACE mRNA for predicting overt DN

From: WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy

Parameters

Threshold values

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

AUC (95% CI)

p value

WT1 mRNA

1.89

67.6

93.0

78.1

88.5

0.83 (0.74, 0.92)

< 0.001

\(\frac{1}{{{\text{ACE}}\;{\text{mRNA}}}}\)

1.80

73.0

72.0

49.0

87.8

0.75 (0.66, 0.83)

< 0.001

  1. AUC area under the curve, PPV positive predictive value, NPV negative predictive value