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Table 5 The diagnostic accuracy of WT1 mRNA and 1/ACE mRNA for predicting overt DN

From: WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy

Parameters Threshold values Sensitivity (%) Specificity (%) PPV (%) NPV (%) AUC (95% CI) p value
WT1 mRNA 1.89 67.6 93.0 78.1 88.5 0.83 (0.74, 0.92) < 0.001
\(\frac{1}{{{\text{ACE}}\;{\text{mRNA}}}}\) 1.80 73.0 72.0 49.0 87.8 0.75 (0.66, 0.83) < 0.001
  1. AUC area under the curve, PPV positive predictive value, NPV negative predictive value