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Table 4 The diagnostic accuracy of WT1 mRNA and 1/ACE mRNA for predicting incipient DN

From: WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy

Parameters Threshold values Sensitivity (%) Specificity (%) PPV (%) NPV (%) AUC (95% CI) p value
WT1 mRNA 1.50 50.0 74.0 55.9 69.1 0.63 (0.55, 0.72) 0.003
\(\frac{1}{{{\text{ACE}}\;{\text{mRNA}}}}\) 1.15 65.2 61.0 52.4 72.6 0.62 (0.54, 0.71) 0.005
  1. AUC area under the curve, PPV positive predictive value, NPV negative predictive value