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Table 3 Stepwise multivariate linear regression analyses on the factors influencing WT1 mRNA and ACE mRNA

From: WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy

Predictor factorsa Unstandardized coefficients Standardized coefficients t p-value*
B SE Beta
Dependent variable: WT1 mRNA
 Constant − 0.024 0.197   − 0.120 0.905
 HbA1c 0.142 0.021 0.426 6.661 < 0.001
 S. Cr 0.236 0.113 0.130 2.081 0.039
 Alb/Cr ratio 0.001 < 0.001 0.322 4.832 < 0.001
Dependent variable: ACE mRNA
 Constant 1.730 0.097   17.829 < 0.001
 HbA1c − 0.113 0.012 − 0.502 − 9.087 < 0.001
 Alb/Cr ratio < 0.001 < 0.001 − 0.176 − 3.190 0.002
  1. FBS fasting blood glucose, S. Cr serum creatinine, Alb/Cr ratio urine albumin/creatinine ratio, SE standard error
  2. aThe following independent variables were adopted for multivariate linear regression analysis of WT1 mRNA: age, FBS, HbA1c, urea, serum creatinine and urine Alb/Cr ratio
  3. *p-value < 0.05 was considered statistically significant