WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy

Table 3 Stepwise multivariate linear regression analyses on the factors influencing WT1 mRNA and ACE mRNA

Predictor factors^a	Unstandardized coefficients		Standardized coefficients	t	p-value*
Predictor factors^a	B	SE	Beta	t	p-value*
Dependent variable: WT1 mRNA
Constant	− 0.024	0.197		− 0.120	0.905
HbA1c	0.142	0.021	0.426	6.661	< 0.001
S. Cr	0.236	0.113	0.130	2.081	0.039
Alb/Cr ratio	0.001	< 0.001	0.322	4.832	< 0.001
Dependent variable: ACE mRNA
Constant	1.730	0.097		17.829	< 0.001
HbA1c	− 0.113	0.012	− 0.502	− 9.087	< 0.001
Alb/Cr ratio	< 0.001	< 0.001	− 0.176	− 3.190	0.002

FBS fasting blood glucose, S. Cr serum creatinine, Alb/Cr ratio urine albumin/creatinine ratio, SE standard error
^aThe following independent variables were adopted for multivariate linear regression analysis of WT1 mRNA: age, FBS, HbA1c, urea, serum creatinine and urine Alb/Cr ratio
*p-value < 0.05 was considered statistically significant

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