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Table 2 Correlations of WT1 mRNA and ACE mRNA with demographic and clinical parameters within total sample, DN group and DM group, separately

From: WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy

  mRNA Age BMI FBS HbA1c Urea S. Cr eGFR Alb/Cr
Total WT1 r 0.222 − 0.167 0.423 0.571 0.193 0.200 0.042 0.509
p 0.004 0.252 < 0.001  < 0.001 0.002 0.001 0.636 < 0.001
ACE r − 0.101 0.180 − 0.402 − 0.592 − 0.135 − 0.177 0.058 − 0.465
p 0.190 0.216 < 0.001 < 0.001 0.032 0.005 0.505 < 0.001
DN group WT1 r 0.161 − 0.207 0.270 0.341 0.020 0.221 − 0.201 0.602
p 0.239 0.565 0.006 < 0.001 0.845 0.025 0.326 < 0.001
ACE r − 0.110 0.250 − 0.340 − 0.445 − 0.021 − 0.159 0.273 − 0.474
p 0.424 0.486 0.001 < 0.001 0.836 0.110 0.177 < 0.001
DM group WT1 r 0.040 − 0.172 0.280 0.518 0.001 0.007 0.138 0.018
p 0.736 0.331 0.005 < 0.001 0.991 0.944 0.262 0.864
ACE r 0.050 0.154 − 0.372 − 0.685 0.064 − 0.025 0.040 − 0.234
p 0.670 0.386 < 0.001 < 0.001 0.526 0.803 0.747 0.020
  1. BMI body mass index, FBS fasting blood glucose, S. Cr serum creatinine, eGFR estimated glomerular filtration rate, Alb/Cr urine albumin/creatinine ratio
  2. r = correlation coefficient of spearman, p = p-value