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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: CHN1 promotes epithelial–mesenchymal transition via the Akt/GSK-3β/Snail pathway in cervical carcinoma

Fig. 2

CHN1 overexpression promotes tumorigenicity in CC cells. a CHN1 was overexpressed in SiHa and Hela cells after transfection. GAPDH was used as the internal control. b Cell proliferation was enhanced after the overexpression of CHN1 in SiHa and Hela cells (data represent means ± SD, n = 3, **p < 0.01). c Foci formation was effectively promoted after CHN1 overexpression in SiHa and Hela cells (data represent means ± SD, n = 3, **p < 0.01). d Xenograft tumors were formed following SiHa-CHN1 and SiHa-Vector transfection in nude mice. 5 × 10^7 CHN1 overexpressed SiHa cells (SiHa-CHN1) or empty vector transfected SiHa cells (SiHa-Vector) were used for xenograft, respectively. Tumors were harvested and assessed 8-week post xenograft (right, n = 5 for each group, **p < 0.01). e Representative H&E and IHC staining for CHN1 expression in CHN1- and empty vector-transfected xenograft tumors (original magnification, ×200)

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