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Table 2 The Baseline Demographic Characteristics and Outcome of the Development and External Validation Set

From: Nomogram for short-term outcome assessment in AChR subtype generalized myasthenia gravis

Variables Subgroups Development set (n = 96) No. of patients (%) Median (range) External validation set (n = 45) No. of patients (%) Median (range) P value
Outcome Non MSE 26 (27.1) 12 (26.7) 0.959
  MSE 70 (72.9) 33 (73.3)  
Gender Male 46 (47.9) 22 (48.9) 0.914
  Female 50 (52.1) 23 (51.1)  
Age at onset EOMG 62 (64.6) 23 (51.1) 0.096
  LOMG 25 (26.0) 12 (26.7)  
  Elderly-onset MG 9 (9.6) 10 (22.2)  
MGFA classification II 62 (64.6) 21 (46.7) 0.128
  III 29 (30.2) 20 (44.4)  
  IV 5 (5.2) 4 (8.9)  
Thymoma No 62 (66.0) 32 (71.1) 0.543
  Yes 32 (34.0) 13 (28.9)  
Thymectomy No 70 (74.5) 41 (91.1) 0.022*
  Yes 24 (25.5) 4 (8.9)  
Worsening No 24 (25.0) 7 (15.6) 0.207
  Yes 72 (75.0) 38 (84.4)  
Autoimmune disease No 86 (89.6) 37 (82.2) 0.222
  Yes 10 (10.4) 8 (17.8)  
Disease duration, months 7 (3.0–30.5) 2 (1.0–6.0) 0.001*
Anti-AChR Abs titer, nmol/L 6 (2.6–10.3) 8 (4.5–20.1) 0.018*
Pyridostigmine dosage, mg/day 180 (90.0–180.0) 180 (0–210.0) 0.528
MMT score 14 (7.0–19.0) 50 (41.5–50)# 0.001*
MG-ADL score 5 (4.0–8.0) 6 (4.0–9.5) 0.151
 Bulbar score 2 (1.0–3.0) 2 (1.0–4.0) 0.026*
 Respiratory score 0 (0–1.0) 0 (0–1.0) 0.540
 Limb score 1 (0–2.0) 0 (0–2.0) 0.651
 Ocular score 3 (1.0–4.0) 3 (2.0–4.0) 0.458
QMG score 11 (9.0–14.0) 10 (7.0–16.5) 0.485
 Extraocular muscle score 3 (1.0–4.0) 3 (2.5–4.5) 0.068
 Bulbar muscle score 0 (0–1.0) 1 (0–3.0) 0.001*
 Respiratory muscle score 0 (0–1.0) 0 (0–1.0) 0.357
 Gross motor score 6 (4.0–8.0) 5 (2.0–8.5) 0.042*
 Axial motor score 1 (1.0–2.0) 1 (0–2.0) 0.097
  1. MSE minimal symptom expression, EOMG early-onset myasthenia gravis, LOMG late-onset myasthenia gravis, MG myasthenia gravis, MGFA Myasthenia Gravis Foundation of America, AChR acetylcholine receptor, Abs antibodies, MMT manual muscle test, MG-ADL myasthenia gravis-activity of daily living, QMG quantitative myasthenia gravis
  2. *Statistical significance (α = 0.05)
  3. #There are only Wuhan No.1 Hospital record the MMT score (n = 9)