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Table 1 The Baseline Demographic Characteristics and Outcome of the Development and Validation Set

From: Nomogram for short-term outcome assessment in AChR subtype generalized myasthenia gravis

Variables Subgroups Development set (n = 96) No. of patients (%) Median (range) Temporal validation set (n = 24) No. of patients (%) Median (range) P value
Outcome Non MSE 26 (27.1) 4 (16.7) 0.292
  MSE 70 (72.9) 20 (83.3)  
Gender Male 46 (47.9) 15 (62.5) 0.201
  Female 50 (52.1) 9 (37.5)  
Age at onset EOMG 62 (64.6) 16 (66.7) 0.815
  LOMG 25 (26.0) 5 (20.8)  
  Elderly-onset MG 9 (9.6) 3 (12.5)  
MGFA classification II 62 (64.6) 16 (66.7) 0.999
  III 29 (30.2) 7 (29.2)  
  IV 5 (5.2) 1 (4.2)  
Thymoma No 62 (66.0) 19 (79.2) 0.213
  Yes 32 (34.0) 5 (20.8) 0.633
Thymectomy No 70 (74.5) 19 (79.2)  
  Yes 24 (25.5) 5 (20.8)  
Worsening No 24 (25.0) 9 (37.5) 0.22
  Yes 72 (75.0) 15 (62.5)  
Autoimmune disease No 86 (89.6) 20 (83.3) 0.619
  Yes 10 (10.4) 4 (16.7)  
Disease duration, months 7 (3.0–30.5) 4 (2.0–14.5) 0.305
Anti-AChR Abs titer, nmol/L 6 (2.6–10.3) 8 (2.6–12.4) 0.316
Pyridostigmine dosage, mg/day 180 (90.0–180.0) 180 (180.0–180.0) 0.557
MMT score 14 (7.0–19.0) 14 (7.3–19.8) 0.743
MG-ADL score 5 (4.0–8.0) 5 (4.0–7.0) 0.377
 Bulbar score 2 (1.0–3.0) 1 (0–2.8) 0.145
 Respiratory score 0 (0–1.0) 0 (0–0) 0.035*
 Limb score 1 (0–2.0) 0 (0–1.0) 0.103
 Ocular score 3 (1.0–4.0) 3 (2.0–4.0) 0.182
QMG score 11 (9.0–14.0) 12 (7.0–16.0) 0.638
 Extraocular muscle score 3 (1.0–4.0) 4 (2.0–5.0) 0.038
 Bulbar muscle score 0 (0–1.0) 1 (0–2.0) 0.110
 Respiratory muscle score 0 (0–1.0) 0 (0–0) 0.002*
 Gross motor score 6 (4.0–8.0) 6 (2.5–8.0) 0.220
 Axial motor score 1 (1.0–2.0) 1 (1.0–2.0) 0.869
  1. MSE minimal symptom expression, EOMG early-onset myasthenia gravis, LOMG late-onset myasthenia gravis, MG myasthenia gravis, MGFA Myasthenia Gravis Foundation of America, AChR acetylcholine receptor, Abs antibodies, MMT manual muscle test, MG-ADL myasthenia gravis-activity of daily living, QMG quantitative myasthenia gravis
  2. *Statistical significance (α = 0.05)