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Table 4 Difference between structural damage and the presence/absence of HLA-B27 on the SPARCC scores or ASDAS-CRP level in nr-axSpA subjects (Mann–Whitney U test)

From: MRI contributes to accurate and early diagnosis of non-radiographic HLA-B27 negative axial spondyloarthritis

Presence ( +) vs. absence (–)

of structural damage

HLA-B27( +)

n = 41

HLA-B27(–)

n = 62

nr-axSpA

n = 103

SPARCC scores

 Sclerosis ( +) vs. (–)

p value

5.77 vs. 0.67

0.002**

2.62 vs. 0.25

0.161

3.98 vs. 0.40

 < 0.001***

 Erosion ( +) vs. (–)

p value

3.90 vs. 0.00

NAc

1.62 vs. 0.50

1

2.57 vs. 0.50

0.663

 JSW ( +) vs. (–)

p value

8.58 vs. 1.97

 < 0.001***

6.36 vs. 0.51

0.005**

7.52 vs. 1.04

 < 0.001***

 DPa ( +) vs. (–)

p value

4.19 vs. 3.36

0.734

1.90 vs. 0.91

0.422

2.82 vs. 1.86

0.942

 TPb ( +) vs. (–)

p value

8.58 vs. 1.97

0.001**

6.90 vs. 0.52

0.005**

7.82 vs. 1.04

 < 0.001***

ASDAS-CRP scores

 Sclerosis ( +) vs. (–)

p value

2.04 vs. 2.02

0.678

2.09 vs. 2.03

1

2.04 vs. 2.06

0.848

 Erosion ( +) vs. (–)

p value

2.03 vs. 0.00

NA

2.23 vs. 2.04

0.308

2.23 vs. 2.04

0.270

 fJSW ( +) vs. (–)

p value

2.38 vs. 1.89

0.034*

2.31 vs. 2.00

0.074

2.34 vs. 1.96

0.010*

 DPa ( +) vs. (–)

p value

2.18 vs. 1.76

0.108

2.14 vs. 1.91

0.199

2.15 vs. 1.85

0.050

 TPb ( +) vs. (–)

p value

2.38 vs. 1.89

0.034*

2.27 vs. 2.02

0.173

2.33 vs. 1.97

0.020*

  1. BME bone marrow edema, SPARCC Spondyloarthritis Research Consortium of Canada, ASDAS Ankylosing Spondylitis Disease Activity Scores, CRP C-reactive protein, fJSW focal joint space widening, nr-axSpA nonradiographic spondyloarthritis, NA not applicable
  2. aDP, double positive, dual presence of sclerosis and erosion on MRI-SIJs
  3. bTP, triple positive, simultaneous presence of sclerosis, erosion, and fJSW on MRI-SIJs
  4. cAll HLA-B27 ( +) patients have erosions on SIJ MRI
  5. *p value < 0.05
  6. **p value < 0.01
  7. ***p value < 0.001