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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: MYBL2-induced PITPNA-AS1 upregulates SIK2 to exert oncogenic function in triple-negative breast cancer through miR-520d-5p and DDX54

Fig. 7Fig. 7

PITPNA-AS1 promoted TNBC cellular processes by targeting the miR-520d-5p/DDX54/SIK2 axis. A SIK2 expression in HCC1937 cell lines transfected with pcDNA3.1 (Vector) or pcDNA3.1/SIK2 (SIK2) was examined via RT-qPCR. B, C The viability and proliferation of transfected cells were determined with CCK-8 and colony formation assays. D Flow cytometry analysis showed the apoptosis in each group. E, F Migration and invasion of cells with indicated transfections were measured by wound healing assay and Transwell assays. G EMT-associated proteins in the HCC1937 cell lines of indicated groups were tested by western blot. *p < 0.05, **p < 0.01, ***p < 0.001

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