Fig. 9

Impacts of hsa_circ_0000520/miR-1296/CDK2 on tumorigenesis in vivo. A Expression of hsa_circ_0000520, miR-1296 and CDK2 determined by RT-qPCR. B Tumor volume in differently treated mice (n = 8/each group). C Images of tumors in differently treated mice. D Tumor weight in differently treated mice (n = 8/each group). *p < 0.05 vs. mice injected with sh-NC-treated cells. ^#p < 0.05 vs. mice injected with miR-1296 inhibitor + sh-NC treated cells. ^&p < 0.05 vs. mice injected with cells transfected with sh-hsa_circ_0000520 + oe-NC. Measurement data are presented as mean ± standard deviation derived from at least 3 independent experiments. Data among multiple groups are compared by one-way ANOVA followed by Tukey’s test. Data at different time points are compared by repeated measures ANOVA followed by Bonferroni’s test