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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation

Fig. 4

Hsa_circ_0000520 promotes CDK2 expression by suppressing miR-1296 expression. A TCGA database analysis results of CDK2 expression in cervical cancer tissues. B CDK2 expression in clinical specimens (n = 52) determined by RT-qPCR. C Binding relation between miR-1296 and CDK2 predicted using a web-based tool and verified by dual luciferase reporter gene assay. D IHC results of CDK2 expression (×200). E CDK2 protein expression positive rate. F Expression of miR-1296 and CDK2 in each group of SiHa cells determined by RT-qPCR. G Expression of miR-1296 and CDK2 in each group of HeLa cells determined by RT-qPCR. H Protein bands of CDK2 detected by Western blot analysis. I Quantitative analysis of CDK2 expression in SiHa cells determined by Western blot analysis. J Quantitative analysis of CDK2 expression in HeLa cells determined by Western blot analysis. *p < 0.05 vs. adjacent normal tissues, mimic NC or sh-NC. Measurement data are presented as mean ± standard deviation derived from at least 3 independent experiments. Data from two groups are compared by independent sample t test. Data from multiple groups are compared by one-way ANOVA followed by Tukey’s test

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