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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation

Fig. 3

Hsa_circ_0000520 targets miR-1296. A Results of TCGA database to analyze the expression of miR-1296 in cervical cancer tissues. B RT-qPCR to detect the expression of miR-1296 in cervical cancer tissues and adjacent normal tissues (n = 52). C Binding relation between hsa_circ_0000520 and miR-1296 predicted using a web-based tool and verified by dual luciferase reporter gene assay. D Expression of mir-1296 detected by RT-qPCR after hsa_circ_0000520 silencing. E, Binding of hsa_circ_0000520 to Ago2 proteins assessed by RIP. *p < 0.05 vs. adjacent normal tissues, sh-NC, mimic NC or IgG. Measurement data are presented as mean ± standard deviation derived from at least 3 independent experiments. Cancerous tissues are compared with adjacent normal tissues using paired t-test. Data from two groups are compared by independent sample t test

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Journal of Translational Medicine

ISSN: 1479-5876

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