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Table 1 Univariate and multivariate analyses of the GSE39582 dataset

From: Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer

Variables

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Age (years)

 < 68

Ref.

 

Ref.

 

 ≥ 68

1.44 (1.06–1.94)

0.02

1.51 (1.09–2.10)

0.01

Adjuvant chemotherapy

  

NE

 

 No

Ref.

   

 Yes

1.01 (0.75–1.37)

0.95

  

Sex

  

NE

 

 Male

Ref.

   

 Female

0.77 (0.57–1.04)

0.09

  

BRAF status

  

NE

 

 Wildtype

Ref.

   

 Mutant

1.05 (0.60–1.81)

0.90

  

KRAS status

 Wildtype

Ref.

 

Ref.

 

 Mutant

1.39 (1.03–1.88)

0.03

1.38 (1.00–1.89)

0.05

TP53 status

  

NE

 

 Wildtype

Ref.

   

 Mutant

1.18 (0.82–1.68)

0.37

  

CIMP status

  

NE

 

 Negative

Ref.

   

 Positive

0.97 (0.63–1.49)

0.90

  

CIN status

  

NE

 

 Negative

Ref.

   

 Positive

0.80 (0.54–1.19)

0.26

  

MMR status

    

 pMMR

Ref.

 

NE

 

 dMMR

0.79 (0.48–1.30)

0.35

  

Tumor location

  

NE

 

 Proximal colon

Ref.

   

 Distal colon

0.91 (0.67–1.23)

0.55

  

CIT subtype

 C4C6

Ref.

 

Ref.

 

 Others

0.61 (0.44–0.84)

0.002

0.92 (0.64–1.34)

0.68

TNM stage

 I + II

Ref.

 

Ref.

 

 III + IV

1.98 (1.45–2.70)

< 0.001

1.52 (1.10–2.11)

0.01

 MRS

15.89 (9.97–25.33)

< 0.001

13.59 (8.12–22.72)

< 0.001

  1. CIMP CpG island methylator phenotype, CIN chromosomal instability, CIT d’identité des tumeurs, MMR mismatch repair, dMMR deficient mismatch repair, pMMR proficient mismatch repair, MRS metabolic risk score, NE not entered
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Journal of Translational Medicine

ISSN: 1479-5876

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