Fig. 4

Circ_001209 regulates HRVECs function. QRT-PCR analysis was used to detect the expressions of circ_001209 (A), miR-15b-5p (B) and COL12A1 (C) in different groups. D Western blot assay was used to detect the protein expression of COL12A1 in different groups. E Wound healing assay was used to detect the invasion of HRVECs in different groups. F Transwell assay was used to detect the migration of HRVECs in different groups. G Tube formation experiment was performed to assess the tubule-forming ability of cells in different groups. The data was presented as mean ± SEM, n = 3 each group. Vs con + ciR-NC group, *P < 0.05, **P < 0.01; vs HG + ciR-NC group, ^#P < 0.05, ^##P < 0.01