Fig. 1

MiR-15b-5p is low expressed in STZ-induced diabetic retinopathy tissues and affects function of HRVECs under high-glucose (HG) conditions. A The relative expression levels of miR-15b-5p, detected by qRT-PCR analysis, in sham group and diabetic rat retinas. B The qRT-PCR analysis was used to detect the expression level of miR-15b-5p in HRVECs induced by HG (25 mM glucose). C The relative expression of miR-15b-5p in HRVECs was detected by qRT-PCR analysis. D Wounding healing assay was performed to detect the invasion ability in different groups. E Transwell assay was used to measure the migration ability in different groups. F The tubule-forming ability of cells was measured by the tubule formation experiment. The data were presented as mean ± SEM, n = 3 each group, vs con/sham group, *P < 0.05, **P < 0.01; vs HG + mimics control group, ^#P < 0.05