Fig. 4

Comparison of the AUC resulting from the SARS-CoV-2-specific responses. A The graph shows the AUC of seven different immune responses based on RANTES induced by NP Pool1; IFN-γ by Spike; IP-10 by Spike; IP-10 by NP Pool2; IL-2 by Spike, IL-2 by ORF3a, a combination of all above cited tests (combined test). Since one observation related to IL-2 induced by ORF3a is missing, the AUC comparison has been performed on 40 patients instead of 41. B Comparison of the single test AUCs with the combined test: *p values referred to correspondent ROC; **comparison of AUCs of NP Pool 1 RANTES, Spike IFN-γ, Spike IP-10, NP Pool 2 IP-10, Spike IL-2, ORF3a IL-2 with the AUC of combined test. C Comparison of the single test AUCs with IP-10 induced by Spike AUC: *p values referred to correspondent ROC; **comparison of AUCs of NP Pool 1 RANTES, Spike IFN-γ, NP Pool 2 IP-10, Spike IL-2, ORF3a IL-2, combined test, with the AUC of Spike IP-10. IL interleukin; IP interferon-γ inducible protein; IFN interferon; RANTES regulated on activation, normal T cell expressed and secreted, NP nucleoprotein, CI confidence interval; AUC area under the curve