Fig. 1

Sparse partial least squares discriminant analysis (sPLS-DA) on luminex data-set of COVID-19 and NO-COVID-19 subjects. The different soluble factors have been measured by luminex assay in plasma collected after stimulating whole-blood with different SARS-CoV-2 peptides (Spike, NP Pool1, NP Pool2, Membrane and ORF3a). A The samples are projected in the space spanned by the first two components with 95% confidence level ellipse plots. Colours and symbols indicate the class of each sample (orange triangle COVID-19 patients, blue circles NO-COVID-19 individuals). B, C Selected immune responses distinguish COVID-19 and NO-COVID-19 individuals over all the evaluated antigens stimulation and distinct immune response detected. The graphs represent the loading weights of the selected variables on each component (20 soluble factors for each component). The variables contribution ranked from the bottom, the most important, to the top. The colors indicate the class for which the selected variable has a maximal mean value: orange COVID-19 patients, blue NO-COVID-19