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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis

Fig. 5

T-5224 inhibits IgE-mediated allergic response in PCA and ASA model. In a PCA test, Balb/c mice were injected intradermally with anti-DNP IgE for 24 h and with intravenous DNP-HSA containing Evans blue. A, B The representative images of ears and photomicrographs of ear sections were stained with toluidine blue as shown. C Ear thickness was measured. D The dye extracted from the ear was detected using a spectrophotometer. E ASA model protocol (n = 6/group). Ketotifen was used as a positive control treatment. F Rectal temperatures were measured every 10 min for 1.5 h. Blood was obtained from the abdominal vein of each mouse to measure serum histamine, IL-4. Serum histamine (G) and IL-4 levels (H) were determined by ELISA. Means ± SDs of 3 independent experiments are shown; *p < 0.05 vs. non-treated mice

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