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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis

Fig. 2

Fos up-regulates transcriptionally the EGR1 expression through binding to EGR1 promoter. A Protein–protein interaction (PPI) network. B, C The gene expression of pro-inflammatory cytokines Egr 1 was analyzed by RT-PCR and Western blot. D, E RT-PCR and Western blot analysis of Egr 1 expression in RBL‑2H3 cells transfected with ShRNA‑Fos. F c Fos binding site on the Egr 1 promoter region was predicted by consulting the JASPAR database. G Interaction of c Fos with Egr 1 promoter region was validated by CHip assay. *p < 0.05 **p < 0.01. Sh-NC, negative control

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Journal of Translational Medicine

ISSN: 1479-5876

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