Table 3 The roles of ecDNA in cancer progression
From: Extrachromosomal circular DNA: a new potential role in cancer progression
Cancer | Oncogene amplification via ecDNA | The connection between ecDNA and tumorigenesis |
|---|---|---|
Neuroblastoma | n-myc | Remodeling the chromosomal genome, amplifying n-myc, promoting the expression of TERT and inhibiting the expression of DCLK1 |
Glioblastoma | EGFR, PDGFRA, ERBB2, KIT | Amplifying a variety of oncogenes, affecting tumor invasiveness, radiation resistance and drug resistance |
Colorectal carcinoma | DHFR | Amplifying DHFR to develop drug resistance |
Ovarian cancer | n-myc, EIF5A2 | Influencing the expression of ecDNA through MARS |
Breast cancer | HER2 | Amplifying HER2 to affect tumor drug resistance |