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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis

Fig. 2

ELK4 is highly expressed in GC tissues and TAMs. A The expression heat map of some differentially expressed genes including hub genes in GC dataset GSE29998. The abscissa represents the sample number, the ordinate represents the gene name, and the left dendrogram represents the expression level clustering. Each small block in the graph represents the expression of a gene in a sample, and the histogram at the upper right is the color scale. B The overlap of significantly different gene in GSE29998 and transcription factors collected in cistrome. C Candidate transcription factor correlation analysis. Each small circle in the graph represents a gene, and the connection between genes indicates that there is correlation between genes. D, The expression of ELK4 gene in GC data collected by TCGA and GTEX. The abscissa represents sample type, ordinate represents expression value, red box diagram represents tumor samples, and the gray box diagram represents normal samples. (T: Tumor; N, Normal; *p < 0.01). E, RT-qPCR was used to detect the relative mRNA expression level of ELK4 in GC and adjacent tissues (n = 30). F, RT-qPCR was used to detect the mRNA expression of ELK4 in GC-TAMs and in Macs in adjacent tissues of GC patients. G, RT-qPCR was used to detect the mRNA expression of ELK4 in GC tissues and GC-TAMs. *p < 0.05

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