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Table 2 Results from CSA, HRR and HRR normalized to CSA

From: The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study

 

Chronic ischemic muscle (gastrocnemius muscle)

Non-ischemic muscle (lateral vastus muscle)

 

Preoperative

Postoperative

p-value

Preoperative

Postoperative

p-value

CSA (nmol/min/mg protein)

    
 

281.4 (252.4–391.8)

438.5 (361.4–471.3)

0.010

310.6 (266.8–357.4)

317.6 (278.3–324.1)

0.940

Mitochondrial respiration [pmol/(s*mg)]

  

 MOctL

16.1 (13.7–18.4)

13.7 (12.2–16.1)

0.575

16.5 (14.1–19.4)

18.3 (16.3–19.9)

0.169

 MOctP

24.4 (20.9–29.7)

20.7 (17.5–22.5)

0.286

26.7 (23.4–29.4)

29.2 (23.3–33.7)

0.205

 P

66.6 (57.8 –78.3)

53.2 (49.8–52.1)

0.006

64.2 (54.2–67.4)

60.2 (54.3–73.2)

0.341

 E

75.9 (59.0–85.1)

59.1 (46.7–64.8)

0.002

69.5 (59.5–75.8)

65.7 (55.7–76.0)

0.617

Mitochondrial respiration [pmol/(s*mg)] per CSA

  

 MOctL

0.048 (0.040–0.074)

0.036 (0.031–0.040)

0.156

0.049 (0.048–0.053)

0.059 (0.049–0.078)

0.176

 MOctP

0.072 (0.060–0.120)

0.051 (0.040–0.063

0.169

0.079 (0.078–0.083)

0.094 (0.079–0.110)

0.326

 P

0.218 (0.196–0.266)

0.132 (0.166–0.150)

0.007

0.185 (0.173–0.230)

0.213 (0.171–0.266)

0.537

 E

0.230 (0.195–0.279)

0.129 (0.120–0.154)

0.005

0.211 (0.180–0.252)

0.196 (0.176–0.243)

0.940

  1. Results from CSA, HRR and HRR normalized to CSA; Data are expressed as median with IQR in brackets; A p-value < 0.05 is considered to be significant; CSA Citrate synthase activity, MOctL maximal respiration after titration of malate and octanoyl, MOctP maximal respiration after addition of ADP, P maximal respiration after addition of pyruvate and succinate, E maximal respiration after addition of FCCP