| |
Chronic ischemic muscle (gastrocnemius muscle)
|
Non-ischemic muscle (lateral vastus muscle)
|
|---|
| |
Preoperative
|
Postoperative
|
p-value
|
Preoperative
|
Postoperative
|
p-value
|
|---|
|
CSA (nmol/min/mg protein)
| | | | |
| |
281.4 (252.4–391.8)
|
438.5 (361.4–471.3)
|
0.010
|
310.6 (266.8–357.4)
|
317.6 (278.3–324.1)
|
0.940
|
|
Mitochondrial respiration [pmol/(s*mg)]
| | |
|
MOctL
|
16.1 (13.7–18.4)
|
13.7 (12.2–16.1)
|
0.575
|
16.5 (14.1–19.4)
|
18.3 (16.3–19.9)
|
0.169
|
|
MOctP
|
24.4 (20.9–29.7)
|
20.7 (17.5–22.5)
|
0.286
|
26.7 (23.4–29.4)
|
29.2 (23.3–33.7)
|
0.205
|
|
P
|
66.6 (57.8 –78.3)
|
53.2 (49.8–52.1)
|
0.006
|
64.2 (54.2–67.4)
|
60.2 (54.3–73.2)
|
0.341
|
|
E
|
75.9 (59.0–85.1)
|
59.1 (46.7–64.8)
|
0.002
|
69.5 (59.5–75.8)
|
65.7 (55.7–76.0)
|
0.617
|
|
Mitochondrial respiration [pmol/(s*mg)] per CSA
| | |
|
MOctL
|
0.048 (0.040–0.074)
|
0.036 (0.031–0.040)
|
0.156
|
0.049 (0.048–0.053)
|
0.059 (0.049–0.078)
|
0.176
|
|
MOctP
|
0.072 (0.060–0.120)
|
0.051 (0.040–0.063
|
0.169
|
0.079 (0.078–0.083)
|
0.094 (0.079–0.110)
|
0.326
|
|
P
|
0.218 (0.196–0.266)
|
0.132 (0.166–0.150)
|
0.007
|
0.185 (0.173–0.230)
|
0.213 (0.171–0.266)
|
0.537
|
|
E
|
0.230 (0.195–0.279)
|
0.129 (0.120–0.154)
|
0.005
|
0.211 (0.180–0.252)
|
0.196 (0.176–0.243)
|
0.940
|
- Results from CSA, HRR and HRR normalized to CSA; Data are expressed as median with IQR in brackets; A p-value < 0.05 is considered to be significant; CSA Citrate synthase activity, MOctL maximal respiration after titration of malate and octanoyl, MOctP maximal respiration after addition of ADP, P maximal respiration after addition of pyruvate and succinate, E maximal respiration after addition of FCCP
