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Table 2 Percentages of living regulatory T (Treg) cells and corresponding conventional T (Tconv) cells from CCS patients and controls, defined as negative for Annexin-V and SYTOX and normalized based on untreated cells (medium only), after 18 h treatment with different concentrations of H2O2 or 2,5 µM STS

From: Oxidative stress response in regulatory and conventional T cells: a comparison between patients with chronic coronary syndrome and healthy subjects

Treatment CCS patients (n = 20) Controls (n = 14) p
Treg cells, % living cells
5 µM H2O2 74 (69–88) 88 (77–94) 0.246
10 µM H2O2 50 (44–58) 58 (41–79) 0.338
20 µM H2O2 9.6 (2.8–11) 14 (8.8–29) 0.159
30 µM H2O2 2.7 (2.2–4.2) 3.9 (2.8–8.9) 0.106
2.5 µM STS 42 (30–52) 47 (40–56) 0.174
  Tconv cells, % living cells  
5 µM H2O2 94 (92–99) 98 (97–100) 0.046
10 µM H2O2 85 (92–99) 93 (87–98) 0.030
20 µM H2O2 39 (35–67) 69 (45–84) 0.110
30 µM H2O2 24 (11–41) 39 (21–57) 0.199
2.5 µM STS 80 (69–91) 91 (88–95) 0.014
  1. Values are given as median (inter-quartile range). CCS, chronic coronary syndrome, H2O2: hydrogen peroxide; STS: staurosporin; Bolded P-values represent statistical significance
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Journal of Translational Medicine

ISSN: 1479-5876

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