Treatment
|
CCS patients (n = 20)
|
Controls (n = 14)
|
p
|
---|
Treg cells, % living cells
|
---|
5 µM H2O2
|
74 (69–88)
|
88 (77–94)
|
0.246
|
10 µM H2O2
|
50 (44–58)
|
58 (41–79)
|
0.338
|
20 µM H2O2
|
9.6 (2.8–11)
|
14 (8.8–29)
|
0.159
|
30 µM H2O2
|
2.7 (2.2–4.2)
|
3.9 (2.8–8.9)
|
0.106
|
2.5 µM STS
|
42 (30–52)
|
47 (40–56)
|
0.174
|
|
Tconv cells, % living cells
| |
---|
5 µM H2O2
|
94 (92–99)
|
98 (97–100)
|
0.046
|
10 µM H2O2
|
85 (92–99)
|
93 (87–98)
|
0.030
|
20 µM H2O2
|
39 (35–67)
|
69 (45–84)
|
0.110
|
30 µM H2O2
|
24 (11–41)
|
39 (21–57)
|
0.199
|
2.5 µM STS
|
80 (69–91)
|
91 (88–95)
|
0.014
|
- Values are given as median (inter-quartile range). CCS, chronic coronary syndrome, H2O2: hydrogen peroxide; STS: staurosporin; Bolded P-values represent statistical significance