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Table 2 Percentages of living regulatory T (Treg) cells and corresponding conventional T (Tconv) cells from CCS patients and controls, defined as negative for Annexin-V and SYTOX and normalized based on untreated cells (medium only), after 18 h treatment with different concentrations of H2O2 or 2,5 µM STS

From: Oxidative stress response in regulatory and conventional T cells: a comparison between patients with chronic coronary syndrome and healthy subjects

Treatment

CCS patients (n = 20)

Controls (n = 14)

p

Treg cells, % living cells

5 µM H2O2

74 (69–88)

88 (77–94)

0.246

10 µM H2O2

50 (44–58)

58 (41–79)

0.338

20 µM H2O2

9.6 (2.8–11)

14 (8.8–29)

0.159

30 µM H2O2

2.7 (2.2–4.2)

3.9 (2.8–8.9)

0.106

2.5 µM STS

42 (30–52)

47 (40–56)

0.174

 

Tconv cells, % living cells

 

5 µM H2O2

94 (92–99)

98 (97–100)

0.046

10 µM H2O2

85 (92–99)

93 (87–98)

0.030

20 µM H2O2

39 (35–67)

69 (45–84)

0.110

30 µM H2O2

24 (11–41)

39 (21–57)

0.199

2.5 µM STS

80 (69–91)

91 (88–95)

0.014

  1. Values are given as median (inter-quartile range). CCS, chronic coronary syndrome, H2O2: hydrogen peroxide; STS: staurosporin; Bolded P-values represent statistical significance