Fig. 2

In vivo efficacy of interstitial-photodynamic therapy (i-PDT) in BxPC3 tumor-bearing mice within 15 days in different groups treated with Photofrin (Phf) and chlorin e6 (Ce6). A, Normalized tumor volumes in mice treated with Phf+Catheter, Phf+LED100J, Phf+LED50J, LED only, and Phf only and untreated mice (n = 4 per group). B, Normalized tumor volumes in mice treated with Ce6+Catheter, Ce6+LED100J, Ce6+LED50J, LED only, and Ce6 only and untreated mice (n = 4 per group). C, Quantitative analysis of CD68-positive cells after indicated treatments. D, Representative images of CD68 staining. Scale bars: 50 mm. Asterisks indicate p values for the comparison of each group of irradiated tumors or nonirradiated tumors by one-way ANOVA. *p< 0.05; **p<0.01; ***p<0.001