Effect of plasma vitamin C levels on Parkinson’s disease and age at onset: a Mendelian randomization study

Table 4 Association of 11 vitamin C genetic variants in PD and PD AAO

SNP	Plasma vitamin C GWAS			PD GWAS			PD AAO GWAS
SNP	EA	NEA	EAF	Beta	SE	P value	Beta	SE	P value
rs10051765	C	T	0.342	0.013	0.019	0.477	0.104	0.125	0.405
rs10136000	A	G	0.283	0.003	0.021	0.872	0.100	0.141	0.478
rs117885456	A	G	0.087	− 0.053	0.043	0.216	0.274	0.267	0.305
rs13028225	T	C	0.857	0.055	0.025	0.024	− 0.325	0.167	0.051
rs174547	C	T	0.328	0.003	0.018	0.853	0.141	0.121	0.243
rs2559850	A	G	0.598	− 0.026	0.023	0.247	0.013	0.141	0.929
rs33972313	C	T	0.968	− 0.006	0.052	0.903	− 0.751	0.353	0.033
rs56738967	C	G	0.321	− 0.034	0.019	0.063	− 0.003	0.125	0.980
rs6693447	T	G	0.551	− 0.034	0.019	0.066	− 0.049	0.125	0.697
rs7740812	G	A	0.594	− 0.034	0.023	0.135	− 0.238	0.143	0.096
rs9895661	T	C	0.817	− 0.002	0.023	0.931	0.032	0.151	0.833

Beta is the regression coefficient based on the vitamin C raising allele (effect allele)
SNP single-nucleotide polymorphism, EA effect allele, NEA non-effect allele, EAF effect allele frequency, SE standard error

ISSN: 1479-5876