Fig. 3
A Relative abundance and numbers of multidimensional significant discrepant metabolism-associated molecular features: mRNA, miRNA, and methylation differentially regulated between HGLO and LGHO across 33 cancer types. B Box plots showing the expression levels of HIF1A (upper) and MPC1 (lower) in HGLO and LGHO subgroup in different cancer types, respectively. Within each group, the scattered dots represent the two scores of each patient. The lines in the boxes represent the median value. The bottom and top of the boxes are the 25th and 75th percentiles (interquartile range). The whiskers encompass 1.5 times the interquartile range. The statistical difference of two scores was compared through the Wilcoxon test. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. C GO functional enrichment analysis of the DEGs (upper 15 pathways for genes up-regulated in HGLO, lower 15 for LGHO). The bar plot indicates number of genes in each pathway, while the dotted lines displays the adjusted P-value of enrichment. BP, biological pathway; CC, cellular component; MF, molecular function. D Common differentially expressed miRNAs (left) and their potential target genes (right) across cancer types. The network (middle) shows the predicted targeting relationship between miRNAs and genes. The bilateral bar plots display the counts of cancer types in which miRNAs or genes are dysregulated (red: up-regulated in HGLO; blue: up-regulated in LGHO)