A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders

Table 4 Associations between infections and alleles implicated in autoimmune disease or mental illness from our previous studies (only associations with P ≤ 0.05 are shown; ORs were calculated before the truncation of some of the decimal places from the estimates)

Allele	Estimate (ln(OR))	Std. error of the estimate	OR (odds ratio)	p-value	Infection category
DQA1*0102	− 0.0292	0.014231	0.971221	0.040168	Any infection
DQA1*0301	0.052435	0.019077	1.053834	0.005984	Any infection
DQB1*0302	0.04346	0.017379	1.044418	0.012395	Any infection
DRB1*0401	0.051723	0.023683	1.053084	0.028967	Any infection
DQA1*0301	0.08244	0.030735	1.085933	0.007311	Gastrointestinal infection
DQB1*0302	0.074499	0.028013	1.077345	0.007826	Gastrointestinal infection
DQA1*0301	0.168838	0.084957	1.183928	0.046885	Genital infection
DRB1*0401	0.230091	0.103525	1.258714	0.026246	Genital infection
DRB1*0801	0.806151	0.353065	2.239273	0.022413	Hepatitis infection
DQA1*0301	0.094638	0.026576	1.099261	0.000369	Other infections
DQB1*0302	0.077648	0.024273	1.080742	0.001379	Other infections
DRB1*0401	0.065745	0.033446	1.067954	0.049336	Other infections
C*0401	0.277345	0.101347	1.319621	0.006208	Pregnancy-related infection
DQA1*0102	− 0.0369	0.018438	0.963772	0.045357	Respiratory infection
DQA1*0301	0.074712	0.024401	1.077574	0.0022	Respiratory infection
DQB1*0302	0.063564	0.022285	1.065628	0.004341	Respiratory infection
DRB1*0401	0.067727	0.030469	1.070073	0.026227	Respiratory infection
C*0702	0.182894	0.089832	1.200687	0.041754	Sepsis
DQA1*0301	0.081349	0.036639	1.084749	0.026398	Skin infection
C*0401	0.193844	0.057718	1.213907	0.000784	Urological infection
DQA1*0102	− 0.03836	0.019028	0.962365	0.0438	Viral infection
DQA1*0301	0.066253	0.025166	1.068497	0.008472	Viral infection
DQB1*0302	0.06831	0.022884	1.070697	0.002835	Viral infection
DRB1*0401	0.089667	0.031349	1.09381	0.004232	Viral infection

ISSN: 1479-5876