A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders

Nudel, Ron; Allesøe, Rosa Lundbye; Thompson, Wesley K.; Werge, Thomas; Rasmussen, Simon; Benros, Michael E.

doi:10.1186/s12967-021-02888-1

Table 3 Results of the allele-based tests for top associations from the gene-based tests (only results for regressions that worked are shown; ORs were calculated before the truncation of some of the decimal places from the estimates)

From: A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders

Infection category	Allele	Estimate (ln(OR))	Std. error of the estimate	OR (odds ratio)	p-value
Sepsis	DQB1*0503	0.559104	0.203687	1.749105	0.006053
Sepsis	DQB1*0301	− 0.24618	0.105892	0.78178	0.020081
Sepsis	DQB1*0602	0.184527	0.095393	1.20265	0.053066
Sepsis	DQB1*0502	− 1.25217	0.710498	0.285883	0.078004
Sepsis	DQB1*0501	0.172764	0.10667	1.188585	0.105317
Sepsis	DQB1*0303	0.212767	0.156171	1.237096	0.173072
Sepsis	DQB1*0302	− 0.14869	0.112826	0.861833	0.187535
Sepsis	DQB1*0603	− 0.20829	0.159683	0.811969	0.192091
Sepsis	DQB1*0609	− 1.14838	1.003663	0.317152	0.252547
Sepsis	DQB1*0402	− 0.23573	0.212697	0.789997	0.267743
Sepsis	DQB1*0201	0.104055	0.126681	1.109661	0.411423
Sepsis	DQB1*0604	− 0.11078	0.161356	0.895133	0.492351
Sepsis	DQB1*0202	0.086373	0.132958	1.090213	0.515934
Sepsis	DQB1*0601	− 0.16911	0.506018	0.844415	0.738229
Other infections	DQA1*0301	0.094638	0.026576	1.099261	0.000369
Other infections	DQA1*0103	− 0.0716	0.03371	0.930902	0.033665
Other infections	DQA1*0601	− 0.46193	0.263865	0.630068	0.080012
Other infections	DQA1*0102	− 0.028	0.020206	0.972385	0.165775
Other infections	DQA1*0401	0.051297	0.045862	1.052635	0.263356
Other infections	DQA1*0303	0.040546	0.037877	1.041379	0.284414
Other infections	DQA1*0201	− 0.02777	0.027843	0.97261	0.318535
Other infections	DQA1*0101	− 0.02144	0.028011	0.978789	0.444044
Other infections	DQA1*0505	0.014933	0.028517	1.015045	0.600533
Other infections	DQA1*0104	0.035278	0.088494	1.035908	0.690147
Other infections	DQA1*0302	− 0.04039	0.117462	0.960416	0.730961
Other infections	DQA1*0501	0.000725	0.030631	1.000725	0.981128
CNS infection	DPB1*1101	− 0.77846	0.452205	0.459111	0.085163
CNS infection	DPB1*1401	1.210008	0.727933	3.353512	0.096462
CNS infection	DPB1*1001	− 0.76275	0.504907	0.46638	0.13087
CNS infection	DPB1*1301	− 0.66143	0.451917	0.516111	0.143299
CNS infection	DPB1*0201	− 0.16001	0.129761	0.852137	0.21754
CNS infection	DPB1*0101	0.179176	0.14896	1.196231	0.229037
CNS infection	DPB1*1601	− 0.61661	0.5786	0.539769	0.286559
CNS infection	DPB1*1501	− 0.6103	0.581432	0.54319	0.293882
CNS infection	DPB1*0301	0.106403	0.113766	1.11227	0.349642
CNS infection	DPB1*0402	0.096617	0.112958	1.101438	0.392365
CNS infection	DPB1*0401	0.053141	0.074281	1.054578	0.474359
CNS infection	DPB1*1901	− 0.25458	0.451412	0.775241	0.572777
CNS infection	DPB1*0501	0.06585	0.210093	1.068066	0.753953
CNS infection	DPB1*1701	0.025801	0.338575	1.026136	0.939257
CNS infection	DPB1*10401^a	− 13.2288	210.2299	1.8E−06	0.949826
Viral infection	DQB1*0302	0.06831	0.022884	1.070697	0.002835
Viral infection	DQB1*0604	− 0.08484	0.034645	0.918659	0.014332
Viral infection	DQB1*0609	− 0.24632	0.13764	0.78167	0.073516
Viral infection	DQB1*0201	0.046721	0.027877	1.04783	0.093743
Viral infection	DQB1*0603	− 0.04453	0.032445	0.956449	0.169931
Viral infection	DQB1*0303	− 0.04964	0.038459	0.951569	0.196766
Viral infection	DQB1*0601	− 0.12332	0.107941	0.88398	0.253254
Viral infection	DQB1*0503	0.058851	0.057194	1.060617	0.303494
Viral infection	DQB1*0202	− 0.0249	0.030592	0.97541	0.41574
Viral infection	DQB1*0301	0.016236	0.021299	1.016369	0.445881
Viral infection	DQB1*0602	− 0.01546	0.022136	0.984661	0.484981
Viral infection	DQB1*0402	− 0.02045	0.04206	0.979754	0.62675
Viral infection	DQB1*0502	0.005057	0.085364	1.00507	0.95276
Viral infection	DQB1*0501	0.000455	0.024834	1.000455	0.985382

^aThe regression analysis for this allele resulted in a large standard error of its estimate due to its low frequency and therefore its effect cannot be determined accurately

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