Fig. 7

METTL13 binds with c-Myc and inhibits c-Myc expression. a Genes interacting with METTL13 were provided by database IntAct (https://www.ebi.ac.uk/intact/) and visualized by software Cytoscape. Each string represents an interaction accession. b The interaction between METTL13 and c-Myc was confirmed by co-immunoprecipitation (Co-IP). c, d Protein levels (c) and mRNA levels (d) of c-Myc were respectively detected by western blot and qRT-PCR after silencing or overexpressing METTL13. Each experiment was performed independently triplicate. Student’s t-test (two-tailed) was used for statistical analysis, *P < 0.05, **P < 0.01, ***P < 0.001. Bar graphs: mean ± S.D., n = 3