Fig. 1

Low expression level of METTL13 is associated with poor prognosis of ccRCCs. a, b METTL13 expression levels in ccRCC tissues and normal kidney tissues according to TCGA database (a) and GSE53757 dataset (b). c, d Expression levels of METTL13 in ccRCC tissues of different tumor grades (c) and of different cancer stages (d) in TCGA dataset. e Kaplan–Meier analysis of ccRCC patients’ overall survival based on METTL13 expression in TCGA database. f, g Relative mRNA levels of METTL13 in 50 ccRCC tissues and their corresponding adjacent normal kidney tissues detected by qRT-PCR assay. h METTL13 protein levels in 13 pairs of ccRCC tumors (T) and their corresponding adjacent normal kidney tissues (N) tested by western blotting. i IHC staining of METTL13 in ccRCC tissues of different pathological grades. Mann-Whitney U-test was performed for statistical analysis for qRT-PCR and western blotting results. **P < 0.01