Fig. 6

Knockdown of eIF6 in HCC cells reduced the capacity of tumorigenesis in vivo. a Images of tumors formed in BALB/c nude mice injected subcutaneously with eIF6-knockdown HepG2 cells (up, n = 6 for each group) and Huh7 cells (down, n = 5 for each group). b The tumor volumes were calculated on the indicated days. c The tumor weights were measured after perfect excision from nude mice. d HE staining and IHC staining of Ki-67 antibody in sections of subcutaneous tumors. Bar = 50 μm. e The Ki-67 index was calculated according to the number of Ki-67-positive cells divided by the number of total cells × 100%. The error bar represents the mean ± SD. *p < 0.05; **p < 0.01