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Table 4 Mean toxicities recorded for HNSCC patients (n = 37) grouped by presence and absence of an alteration in certain genes

From: Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma

Group

Early mucositis (mean)

Early dysphagia (mean)

Late xerostomia (mean)

Late dysphagia (mean)

Combined toxicity (mean)

ATR (BRCA2 Var (+)) N = 4

2.5

1.25

0.75

1.5

6

ATR (BRCA2 Var (−)) N = 2

2.5

1

1

1.5

6

% Change

0

25

− 25

0

0

ERBB3 (BRCA2 Var (+)) N = 2

3

3.5

2

3

11.5

ERBB3 (BRCA2 Var (−)) N = 3

2.33

1.67

1

1

6

% Change

28.57

110

100

200

91.67

TP53 (BRCA2 Var (+)) N = 4

2.5

2

1.25

2

7.75

TP53 (BRCA2 Var (−)) N = 20

2.05

1.25

1

1.65

5.95

% Change

21.95

60

25

21.21

30.25

NOTCH1 (BRCA2 Var (+)) N = 4

2.5

1.5

1.5

2

7.5

NOTCH1 (BRCA2 Var (−)) N = 6

2.5

1.33

1

1

5.83

% Change

0

12.5

50

100

28.57

PIK3CA (BRCA2 Var (+)) N = 3

3

0.67

1.33

1

6

PIK3CA (BRCA2 Var (−)) N = 6

2.5

0.67

1.17

1.33

5.67

% Change

20

0

14.29

− 25

5.88

CDKN2A (BRCA2 Var (+)) N = 5

2.8

1.8

1.2

2

7.8

CDKN2A (BRCA2 Var (−)) N = 16

1.75

1.25

0.94

1.81

5.75

% Change

60

44

28

10.34

35.65

CCND1 (BRCA2 Var (+)) N = 2

2

2

1

2.5

7.5

CCND1 (BRCA2 Var (−)) N = 8

1.75

1.5

1.13

2

6.38

% Change

14.29

33.33

− 11.11

25

17.65

FAT1 (BRCA2 Var (+)) N = 3

2.33

1.33

0.67

1.67

6

FAT1 (BRCA2 Var (−)) N = 13

1.77

0.92

1.08

1.85

5.62

% Change

31.89

44.44

− 38.1

− 9.72

6.85

  1. For each gene, the % change is calculated in respect to the BRCA2 (−) cohort. Toxicities are graded by CTCAE criteria