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Table 3 Mean toxicities recorded for HNSCC patients (n = 37) grouped by presence of an alteration in a certain gene

From: Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma

Group

Early mucositis (mean)

Early dysphagia (mean)

Late xerostomia (mean)

Late dysphagia (mean)

Combined toxicity (mean)

BRCA2 Var (+) N = 8

2.5

1.75

1.38

1.88

7.5

BRCA2 Var (−) N = 29

1.9

1.21

1

1.79

5.9

% Change

31.82

45

37.5

4.57

27.19

Bivariate

p = 0.04

p = 0.07

p = 0.18

p = 0.74

p = 0.10

ATR Var (+) N = 6

2.5

1.17

0.83

1.5

6

ATR Var (−) N = 31

1.94

1.35

1.13

1.87

6.29

% Change

29.17

− 13.89

− 26.17

− 19.83

− 4.62

Bivariate

p = 0.05

p = 0.64

p = 0.30

p = 0.38

p = 0.81

ERBB3 Var (+) N = 5

2.6

2.4

1.4

1.8

8.2

ERBB3 Var (−) N = 32

1.94

1.16

1.03

1.81

5.94

% Change

34.19

107.57

35.76

− 0.69

38.11

Bivariate

p = 0.17

p = 0.05

p = 0.07

p = 0.71

p = 0.92

TP53 Var (+) N = 24

2.13

1.38

1.04

1.71

6.25

TP53 Var (−) N = 13

1.85

1.23

1.15

2

6.23

% Change

15.1

11.72

− 9.72

− 14.58

0.31

Bivariate

p = 0.87

p = 0.9

p = 0.46

p = 0.58

p = 0.04

NOTCH1 Var (+) N = 10

2.5

1.4

1.2

1.4

6.5

NOTCH1 Var (−) N = 27

1.85

1.3

1.04

1.96

6.15

% Change

35

8

15.71

− 28.68

5.72

Bivariate

p = 0.03

p = 0.72

p = 0.08

p = 0.34

p = 0.56

PIK3CA Var (+) N = 9

2.67

0.67

1.22

1.22

5.78

PIK3CA Var (−) N = 28

1.82

1.54

1.04

2

6.39

% Change

46.41

− 56.59

18.01

38.89

-9.62

Bivariate

p = 0.01

p = 0.05

p = 0.39

p = 0.02

p = 0.76

CDKN2A Var (+) N = 21

2

1.38

1

1.86

6.24

CDKN2A Var (−) N = 16

2.06

1.25

1.19

1.75

6.25

% Change

− 3.03

10.48

− 15.79

6.12

− 0.19

Bivariate

p = 0.90

p = 0.94

p = 0.88

p = 0.13

p = 0.97

CASP8 Var (+) N = 6

1.67

1

1

1.5

5.17

CASP8 Var (−) N = 31

2.1

1.36

1.1

1.87

6.45

% Change

− 20.51

− 26.67

− 8.82

− 19.83

− 19.92

Bivariate

p = 0.96

p = 0.64

p = 0.81

p = 0.96

p = 0.52

NFE2L2 Var (+) N = 4

2.5

1.6

1

1.5

6.25

NFE2L2 Var (−) N = 33

1.9

1.48

1.09

1.85

6.24

% Change

31.82

− 66.3

− 8.33

− 18.85

0.12

Bivariate

p = 0.04

p = 0.97

p = 0.49

p = 0.75

p = 0.10

CCND1 Var (+) N = 10

2.5

1

1

2.1

6.6

CCND1 Var (−) N = 27

1.9

1.57

1.07

1.7

6.11

% Change

31.82

− 36.36

2.41

23.26

8

Bivariate

p = 0.04

p = 0.64

p = 0.71

p = 0.56

p = 0.10

ESR1 Var (+) N = 6

2.5

1.33

0.83

0.83

4

ESR1 Var (−) N = 31

1.9

0.92

1.13

2

6.68

% Change

31.82

44.44

− 26.19

− 58.33

− 40.1

Bivariate

p = 0.04

p = 0.14

p = 0.30

p = 0.07

p = 0.01

FAT1 Var (+) N = 16

2.5

1.33

1

1.81

5.69

FAT1 Var (−) N = 21

1.9

0.92

1.14

1.81

6.67

% Change

31.82

44.44

− 12.5

0.16

− 14.69

Bivariate

p = 0.04

p = 0.06

p = 0.92

p = 0.71

p = 0.06

  1. For each gene, the % change is calculated in relation to the altered (−) group. Toxicities are graded by CTCAE criteria