Group | Early mucositis (mean) | Early dysphagia (mean) | Late xerostomia (mean) | Late dysphagia (mean) | Combined toxicity (mean) |
---|---|---|---|---|---|
BRCA2 Var (+) N = 8 | 2.5 | 1.75 | 1.38 | 1.88 | 7.5 |
BRCA2 Var (−) N = 29 | 1.9 | 1.21 | 1 | 1.79 | 5.9 |
% Change | 31.82 | 45 | 37.5 | 4.57 | 27.19 |
Bivariate | p = 0.04 | p = 0.07 | p = 0.18 | p = 0.74 | p = 0.10 |
ATR Var (+) N = 6 | 2.5 | 1.17 | 0.83 | 1.5 | 6 |
ATR Var (−) N = 31 | 1.94 | 1.35 | 1.13 | 1.87 | 6.29 |
% Change | 29.17 | − 13.89 | − 26.17 | − 19.83 | − 4.62 |
Bivariate | p = 0.05 | p = 0.64 | p = 0.30 | p = 0.38 | p = 0.81 |
ERBB3 Var (+) N = 5 | 2.6 | 2.4 | 1.4 | 1.8 | 8.2 |
ERBB3 Var (−) N = 32 | 1.94 | 1.16 | 1.03 | 1.81 | 5.94 |
% Change | 34.19 | 107.57 | 35.76 | − 0.69 | 38.11 |
Bivariate | p = 0.17 | p = 0.05 | p = 0.07 | p = 0.71 | p = 0.92 |
TP53 Var (+) N = 24 | 2.13 | 1.38 | 1.04 | 1.71 | 6.25 |
TP53 Var (−) N = 13 | 1.85 | 1.23 | 1.15 | 2 | 6.23 |
% Change | 15.1 | 11.72 | − 9.72 | − 14.58 | 0.31 |
Bivariate | p = 0.87 | p = 0.9 | p = 0.46 | p = 0.58 | p = 0.04 |
NOTCH1 Var (+) N = 10 | 2.5 | 1.4 | 1.2 | 1.4 | 6.5 |
NOTCH1 Var (−) N = 27 | 1.85 | 1.3 | 1.04 | 1.96 | 6.15 |
% Change | 35 | 8 | 15.71 | − 28.68 | 5.72 |
Bivariate | p = 0.03 | p = 0.72 | p = 0.08 | p = 0.34 | p = 0.56 |
PIK3CA Var (+) N = 9 | 2.67 | 0.67 | 1.22 | 1.22 | 5.78 |
PIK3CA Var (−) N = 28 | 1.82 | 1.54 | 1.04 | 2 | 6.39 |
% Change | 46.41 | − 56.59 | 18.01 | 38.89 | -9.62 |
Bivariate | p = 0.01 | p = 0.05 | p = 0.39 | p = 0.02 | p = 0.76 |
CDKN2A Var (+) N = 21 | 2 | 1.38 | 1 | 1.86 | 6.24 |
CDKN2A Var (−) N = 16 | 2.06 | 1.25 | 1.19 | 1.75 | 6.25 |
% Change | − 3.03 | 10.48 | − 15.79 | 6.12 | − 0.19 |
Bivariate | p = 0.90 | p = 0.94 | p = 0.88 | p = 0.13 | p = 0.97 |
CASP8 Var (+) N = 6 | 1.67 | 1 | 1 | 1.5 | 5.17 |
CASP8 Var (−) N = 31 | 2.1 | 1.36 | 1.1 | 1.87 | 6.45 |
% Change | − 20.51 | − 26.67 | − 8.82 | − 19.83 | − 19.92 |
Bivariate | p = 0.96 | p = 0.64 | p = 0.81 | p = 0.96 | p = 0.52 |
NFE2L2 Var (+) N = 4 | 2.5 | 1.6 | 1 | 1.5 | 6.25 |
NFE2L2 Var (−) N = 33 | 1.9 | 1.48 | 1.09 | 1.85 | 6.24 |
% Change | 31.82 | − 66.3 | − 8.33 | − 18.85 | 0.12 |
Bivariate | p = 0.04 | p = 0.97 | p = 0.49 | p = 0.75 | p = 0.10 |
CCND1 Var (+) N = 10 | 2.5 | 1 | 1 | 2.1 | 6.6 |
CCND1 Var (−) N = 27 | 1.9 | 1.57 | 1.07 | 1.7 | 6.11 |
% Change | 31.82 | − 36.36 | 2.41 | 23.26 | 8 |
Bivariate | p = 0.04 | p = 0.64 | p = 0.71 | p = 0.56 | p = 0.10 |
ESR1 Var (+) N = 6 | 2.5 | 1.33 | 0.83 | 0.83 | 4 |
ESR1 Var (−) N = 31 | 1.9 | 0.92 | 1.13 | 2 | 6.68 |
% Change | 31.82 | 44.44 | − 26.19 | − 58.33 | − 40.1 |
Bivariate | p = 0.04 | p = 0.14 | p = 0.30 | p = 0.07 | p = 0.01 |
FAT1 Var (+) N = 16 | 2.5 | 1.33 | 1 | 1.81 | 5.69 |
FAT1 Var (−) N = 21 | 1.9 | 0.92 | 1.14 | 1.81 | 6.67 |
% Change | 31.82 | 44.44 | − 12.5 | 0.16 | − 14.69 |
Bivariate | p = 0.04 | p = 0.06 | p = 0.92 | p = 0.71 | p = 0.06 |