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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Exosomal lncRNA UCA1 modulates cervical cancer stem cell self-renewal and differentiation through microRNA-122-5p/SOX2 axis

Fig. 4

Down-regulated UCA1 or up-regulated miR-122-5p decreases SOX2 expression and the invasion and migration of CD133+CaSki cells. a RT-qPCR verified UCA1, miR-122-5p and SOX2 mRNA expression. b Western blot assay detected SOX2, OCT4 and Nanog protein expression. c Effect of UCA1 and miR-122-5p on would healing distance of CD133+CaSki cells. d Effect of UCA1 and miR-122–5 on invasion and migration of CD133+CaSki cells. N = 3, * P < 0.05 vs. the Exo + siRNA-NC group, # P < 0.05 vs. the Exo + mimic-NC group. & P < 0.05 vs. the Exo + pcDNA-UCA1 + mimic-NC group. Measurement data were depicted as mean ± standard deviation, comparisons among multiple groups were assessed by one-way analysis of variance followed with LSD-t

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