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Table 1 Pre-clinical studies: MSCs transplantation in ARDS

From: Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment

Study Injury model Source Dosage Route of delivery Primary outcomes
Florian et al. (2021) Mouse-ARDS/LPS Mouse BM-MSCs 2.5 × 105 I.V ↓Neutrophils in BALF (~ 28% decrease), lung inflammation (TNFα: ~ 43% decrease, IFNγ: ~ 73% decrease)
Zhang et al. (2020) Mouse-ARDS/LPS Mouse BM-MSCs 5 × 105 I.V ↑ATP levels (~ 40% increase), oxygen consumption rate (~ 95% increase)
↓Lung inflammation (IL-1β: ~ 58% decrease, TNFα: ~ 29% decrease), reactive oxygen species
Yudhawati et al. (2020) Mouse-ARDS/H5N1 virus Mouse BM-MSCs 5.5 × 105 I.V ↑PaO2/FiO2 ratio (~ 30% increase)
↓Protein in BALF (~ 58% decrease), lung inflammation (NFκB: ~ 47% decrease, TNFα: ~ 55% decrease)
Sadeghian et al. (2020) Sheep-ARDS/LPS Sheep BM-MSCs 5 × 107 I.T ↑PO2 (~ 21% increase), SatO2 (~ 6% increase)
↓Neutrophils in BALF (~ 22% decrease), PCO2 (~ 14% decrease)
Lu et al. (2020) Mouse-ARDS/LPS Mouse BM-MSCs 5 × 105 I.V ↑DCregs
↓mDCs
Cheng et al. (2020) Rat-ARDS/LPS Rat LR-MSCs 2 × 106 I.T ↓Lung inflammation (TNFα: ~ 36% decrease, MCP-1: ~ 31% decrease, IL10: ~ 32% increase)
Chen et al. (2020) Mouse-ARDS/LPS Mouse BM-MSCs 2 × 105 I.T ↓Lung inflammation (IL-17A: ~ 33% decrease, IL10: ~ 25% increase), Th17/Treg (~ 53% decrease)
Radwan et al. (2020) Rat-lung injury/Amiodarone Rat AD-MSCs 2 × 106, 4 × 106 I.V ↓Pulmonary fibrosis
Jung et al. (2019) Mouse-ARDS/LPS Human AD-MSCs 2 × 105 I.V ↓Lung injury score (~ 44% decrease)
Dong et al. (2019) Mouse-ARDS/LPS Mouse BM-MSCs 5 × 104 I.T ↓Lung edema (~ 27% decrease), pulmonary fibrosis
  1. AD-MSCs adipose-derived mesenchymal stem cells, AECs alveolar epithelial cells, ARDS acute respiratory distress syndrome, BALF bronchial alveolar lavage fluid, BM-MSCs bone marrow-derived mesenchymal stem cells, DCs dendritic cells, IFNs interferons, I.P. intraperitoneal, I.T. intratracheal, I.V. Intravenous, LR-MSCs lung-resident mesenchymal stem cells, LPS lipopolysaccharides, NETs neutrophil extracellular traps, mDCs mature dendritic cells, DCregs regulatory dendritic cells, Th17 T helper 17, Tregs regulatory T cells, UC-MSCs umbilical cord-derived mesenchymal stem cells