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Table 3 The impact of EV derived miRNA on neurological and metabolic disease

From: Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis

EV sRNA EV origination Function References
hsa-miR-23a-3p, hsa-miR-126-3p, hsa-let-7i-5p, hsa-miR-151a-3p
(Downregulated)
Plasma Unknown in Alzheimer's disease [123]
miR-212 and miR-132
(Downregulated)
Neurally derived plasma EV Unknown in Alzheimer's disease [124]
miR-23a-3p, miR-223-3p, miR-190a-5p, miR-100-3p,
(Downregulated)
Neurally Derived Plasma EV Unknown in Alzheimer's disease [125]
miRNA cargo
(periodontal bacteria)
Aggregatibacter actinomycetemcomitans Neuroinflammation in Alzheimer's disease [165]
miR-27b,miR-126
miR-130, miR-296
Pancreatic islets Beta cell-endothelium cross-talk in diabetes [165]
miR-221-3p
(up regulated)
Perivascular adipose tissue Vascular remodeling in obesity [168]
miR-1
(up regulated)
Steatotic hepatocytes Atherogenesis in Non-alcoholic fatty liver disease [170]
miR-136-3p, miR-4798-5p
miR-12,136, miR-222-3p
(Downregulated)
miR-630, miR-144-3p, miR-143-5p, miR-4787-3p miR-769-5p, miR-8074, miR-181a-5p)
(up regulated)
Mesenchymal stem cells Renal tubular cells senescence in metabolic syndrome [171]