Table 3 The impact of EV derived miRNA on neurological and metabolic disease

hsa-miR-23a-3p, hsa-miR-126-3p, hsa-let-7i-5p, hsa-miR-151a-3p

(Downregulated)

Plasma

Unknown in Alzheimer's disease

[123]

miR-212 and miR-132

(Downregulated)

Neurally derived plasma EV

Unknown in Alzheimer's disease

[124]

miR-23a-3p, miR-223-3p, miR-190a-5p, miR-100-3p,

(Downregulated)

Neurally Derived Plasma EV

Unknown in Alzheimer's disease

[125]

miRNA cargo

(periodontal bacteria)

Aggregatibacter actinomycetemcomitans

Neuroinflammation in Alzheimer's disease

[165]

miR-27b,miR-126

miR-130, miR-296

Pancreatic islets

Beta cell-endothelium cross-talk in diabetes

[165]

miR-221-3p

(up regulated)

Perivascular adipose tissue

Vascular remodeling in obesity

[168]

miR-1

(up regulated)

Steatotic hepatocytes

Atherogenesis in Non-alcoholic fatty liver disease

[170]

miR-136-3p, miR-4798-5p

miR-12,136, miR-222-3p

(Downregulated)

miR-630, miR-144-3p, miR-143-5p, miR-4787-3p miR-769-5p, miR-8074, miR-181a-5p)

(up regulated)

Mesenchymal stem cells

Renal tubular cells senescence in metabolic syndrome

[171]