Fig. 4

Metformin inhibits mRNA expression of Th17 differentiation-related genes in murine splenocytes. Levels of IL-17, IL-1β, IL-6, and TNF-α in stimulated cells were reduced in metformin-treated groups under anti-CD3 stimulation. *P < 0.05, *P < 0.05, **P < 0.01, and ***P < 0.005