Fig. 9

TILs are associated with specific copy number alterations and fusions in DDLPS. Samples were split into three equally sized groups based on their TIL score. The oncoprint shows genomic alterations enriched in the lower (a) and upper (b) TIL score tertile for DDLPS. In this sarcoma subtype, amplifications and fusions were most abundant. For each group and gene, the percentage of samples with at least one alteration is given. Additionally, the bottom heatmaps show matched gene expression data (pink: not available). In the low TIL group, 12q21.1 amplification affected the genes LGR5, TSPAN8, TRHDE, RAB21, TBC1D15 and TRHDE-AS1, whereas an amplification of 12q23.1 including ELK3, CDK17 and LTA4H was enriched in samples from high and intermediate TIL score expression tertiles