Fig. 2

Potential value of a radiomic feature for interpreting CT images in lung cancer screening. LongHEM: long-run high gray-level emphasis mean. In (a), the distributions of LongHEM was compared between nodules with different types. In (b), the status of the nodules was classified by the end of the study. In (c), the regression slope is 0.610 vs. 0.034 increase per log[day] for the relative change in LongHEM vs. diameter. One influential data point (1.71, 21.52) for the temporal change in LongHEM is not shown, which corresponds to a relative change of 21.52 in LongHEM in 51 days from baseline to the first repeat screen in a patient finally diagnosed with lung adenocarcinoma. In (d), the temporal changes of LongHEM and diameter of a malignant nodule were compared