Fig. 4

a Apoptosis induced by various treatments at 24 h (**P < 0.01, ***P < 0.001, ****P < 0.0001, unpaired t test, combination treatments versus single treatments). b THP-1, HL-60 cells were treated with ST1326 and ABT199, alone or combined, for 24 h. Western blot of Caspase-3, cleaved Caspase-3 and PARP-1 in AML cells. c THP-1 and HL-60 cells were treated with ST1326 and ABT199, alone or combined, for 24 h. Western blot of Bcl‐2, Bax, Bad, Bcl‐xL, Mcl-1 and Bim in AML cells.d THP-1 and HL-60 cells were treated with increasing doses of ABT199 for 24 h. Western blot analysis was conducted for Mcl-1 protein levels