Fig. 1

Identification of the immune class of CC and the molecular characterization of the subgroups. a NMF analysis of whole-tumour gene expression data using a molecular signature able to identify the immune class of CC. In the heatmap, high and low gene set enrichment scores are represented in red and blue, respectively; the same representation is used for high and low gene expression. b An integrated analysis of these immune molecular subgroups with the three published molecular classes. c The five modules of the immune subgroups are indicated by the heatmap. High and low scores are represented in red and blue, respectively. d Correlation of key immune characteristics with immune subgroups. e Infiltration of immune cells by immune subgroups. *p < 0.05; **p < 0.01; ***p < 0.001