Table 1 Characteristics of included studies
Author(s) | Year | Sample size | Injury level (C/T/L) | Treatment/control | M/F | Age (years) | ASIA(A/B/C/D) | Duration | Cell source | Way of transplantation | Cell number | Transplantation times | Follow up (months) | Outcomes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Song et al. [17] | 2020 | 36 | 10/4/4 | 18/18 | 12/6 | 41.2 ± 2.3 | – | – | Auto, bone marrow | IT | 2.0 × 107 | 2 | 12 | ①②④ |
11/5/2 | 10/8 | 41.7 ± 2.1 | ||||||||||||
Zhang et al. [18] | 2019 | 100 | 0/42/8 | 50/50 | 30/20 | 41.26 ± 9.74 | 0/16/20/14 | 6.55 ± 2.43 h | Allo, umbilical cord | IT | (3–4) × 107/ml | 4–6 | 3,6,12 | ①②④⑤ |
0/44/6 | 28/22 | 42.89 ± 10.30 | 0/15/22/13 | 6.80 ± 2.66 h | ||||||||||
Tang et al. [19] | 2016 | 60 | 0/13/17 | 30/30 | 21/9 | 38.2 ± 6.7 | – | – | Auto, bone marrow | IT | 1 × 106 | 1 | 12.4 ± 2.3 | ①②③ |
0/14/16 | 20/10 | 37.9 ± 7.2 | ||||||||||||
Zhang et al. [20] | 2015 | 30 | 10/5/0 | 15/15 | 11/4 | 35.5 ± 8.3 | 9/3/3/0 | 21.3 ± 5.7 months | Allo, umbilical cord | IL | 8 × 107 | 2 | 6 | ①②④ |
10/5/0 | 11/4 | 35.7 ± 8.3 | – | 19.7 ± 7.6 months | ||||||||||
Zhang et al. [21] | 2015 | 100 | – | 50/50 | 16/34 | 36.4 ± 1.9 | – | – | Auto, bone marrow | – | (2–4) × 102 /kg | – | 6 | ①②③ |
15/35 | 37.3 ± 2.0 | |||||||||||||
Cheng et al. [22] | 2014 | 20 | – | 10/10 | – | 35.30 ± 8.23 | 10/0/0/0 | 21.40 ± 12.96 months | Allo, umbilical cord | IL | 4 × 107 | 2 | 6 | ①②③④ |
36.64 ± 9.90 | 10/0/0/0 | 18.57 ± 11.35 months | ||||||||||||
El-kheir et al. [23] | 2014 | 70 | 10/40/0 | 50/20 | 61/9 | 16–45 | 15/35/0/0 | 18.3 ± 5.0 months | Auto, bone marrow | IT | 2 × 106 cells/kg | – | 18 | ①②⑤ |
7/13/0 | 10/10/0/0 | |||||||||||||
Guo et al. [24] | 2014 | 80 | 17/3/20 | 40/40 | 30/10 | 36.4 ± 1.9 | – |  > 1 month | Auto, bone marrow | IL | (2–4) × 102/kg | 2 | 3 | ①②③④ |
13/3/24 | 33/7 | 37.3 ± 2.0 | ||||||||||||
Xiao et al. [25] | 2014 | 64 | 7/12/16 | 35/29 | 23/12 | 42.8 ± 10.2 | – | 22.7 ± 5.4 days | Auto, bone marrow | IT | (8.47 ± 3.54) × 107 | 2 | 6 | ①②④ |
6/10/13 | 19/10 | 41.4 ± 10.5 | ||||||||||||
Dai et al. [26] | 2013 | 40 | 20/0/0 | 20/20 | 14/6 | 34.7 ± 8.9 | 20/0/0/0 | 51.9 ± 18.3 months | Auto, bone marrow | IL | 8 × 105 | 1 | 6 | ①②④⑤ |
20/0/0 | 14/6 | 35.1 ± 8.0 | 20/0/0/0 | 43.2 ± 15.3 months | ||||||||||
Xiao et al. [27] | 2012 | 96 | 7/15/16 (IT) | 38/32/26 | 25/13 | 42.3 ± 10.2 | – | 25.2 ± 6.7 days | Auto, bone marrow | IT and IV | (13.58 ± 4.62) × 106 | 1 | 6 | ①②④ |
6/12/14(IV) | 21/11 | 41.5 ± 10.7 | (13.58 ± 4.62) × 106 | |||||||||||
5/9/12 (Re) | 17/09 | 41.2 ± 10.6 | ||||||||||||
Guo et al. [28] | 2012 | 24 | – | 12/12 | 11/1 | 29 | – | 2.3–2.5 months | Allo, umbilical cord | IT | (2–5) × 107 | 4 | 6 | ①②③ |
10/2 | 31 | |||||||||||||
Dai et al. [29] | 2012 | 23 | 10/11/2 | 15/8 (Auto/Allo) | 16/7 | 28.22 ± 16.19 | – | 1–72 months | Auto, bone marrow | IT | 1–1.5 × 108↑ | 4–6 | 3 | ①② |
Allo, umbilical cord | ||||||||||||||
Zhang et al. [30] | 2012 | 60 | 12/20/28 | 30/30 | 50/10 | 32.5 ± 4.2 | – | 1–10 months | Allo, umbilical cord | IV | 3 × 108 | 1 | 3 | ①②③④ |
Li [31] | 2012 | 30 | 5/8/1 | 14/15 | 11/3 | 37.36 ± 11.06 | 8/4/3/0 | 1 month–9 years | Allo, umbilical cord | IV and IT | 5 × 107 | – | 4 | ①②③④ |
4/10/1 | 10/5 | 37.67 ± 11.84 | 7/4/4/0 | |||||||||||
Kishk et al. [32] | 2010 | 64 | 6/37/0 | 43/20 | 36/7 | 31.7 ± 10.4 | – | 3.6 ± 2.5 years | Auto, bone marrow | IT | 3.75 × 108 to | 6 | 6 | ①②④⑤ |
2/18/0 | 15/5 | 33.8 ± 11.8 | 3.7 ± 2.1 years | 7.5 × 108 | ||||||||||
Abdelaziz et al. [33] | 2010 | 30 | 0/20/0 | 20/10 | 18/2 | 6.0–52.0 | – | 27.2 months | Auto, bone marrow | IL | 5 million cells/kg | 6 | 12 | ④⑤ |
0/10/0 | 07/3 | 6.0–64.0 | ||||||||||||
Xie et al. [34] | 2007 | 24 | 2/4/5 | 11/13 | 9/2 | 18.0–49.0 | 8/0/1/2 | 1–12 months | Auto, bone marrow | IT or IV | (4.87–8.8) × 107 | 3 | 3 | ①③④⑤ |
3/4/6 | 10/3 | 21.0–53.0 | 9/1/2/1 |