Fig. 7

Relationship between (changes in) gut abundance of inferred MetaCyc pathways and (changes in) zonulin/calprotectin levels. a The common slope model (LRT, df = 1, P = 3.98e−6, Q = 0.001) illustrating relationships between PENTOSE-P-PWY change (centered log-ratio transformed) and zonulin change (rank transformed), b the model with time point pair by PWY-6545 change interaction (LRT, df = 9, P = 4.15e−5, Q = 0.014), c common slope model illustrating relationships between CENTFERM-PWY change (centered log-ratio transformed) and calprotectin change (rank transformed), d common slope model illustrating relationships between PWY-6590 change (centered log-ratio transformed) and calprotectin change (rank transformed); Likelihood ratio test (LRT) P- and Q-values were computed based on 128 Monte Carlo instances of the Dirichlet distribution, followed by center-log transform of each instance, the plots were based on the first Monte Carlo instance