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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life

Fig. 4

Alpha and beta diversity (Bray–Curtis distance) compared to zonulin and calprotectin. a Repeated measures correlation between calprotectin and Shannon diversity index. b Repeated measures correlation between zonulin and PCo1 scores, c Repeated measures correlation between calprotectin and PCo2 scores, d Correlation between Bray–Curtis distance and calprotectin change for all possible time point pairs. Significant likelihood ratio test (LRT) indicating an interaction between time period and calprotectin change (df = 9, P = 0.013, Q = 0.025), post-hoc test revealed significant correlations between Bray–Curtis distance and calprotectin change between P2 and P3 (β = 2.18e−03, P = 0.043) and P3 and P4 (β = − 2.31e−03, P = 0.011); alpha diversity, zonulin calprotectin and calprotectin change were rank transformed, repeated measures and correlation trend lines are coloured by individual child. PCo1 and PCo2 scores were treated here as a dimensionality-reduced measure of sample composition relative to whole-dataset variability

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