Fig. 4From: The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of lifeAlpha and beta diversity (Bray–Curtis distance) compared to zonulin and calprotectin. a Repeated measures correlation between calprotectin and Shannon diversity index. b Repeated measures correlation between zonulin and PCo1 scores, c Repeated measures correlation between calprotectin and PCo2 scores, d Correlation between Bray–Curtis distance and calprotectin change for all possible time point pairs. Significant likelihood ratio test (LRT) indicating an interaction between time period and calprotectin change (df = 9, P = 0.013, Q = 0.025), post-hoc test revealed significant correlations between Bray–Curtis distance and calprotectin change between P2 and P3 (β = 2.18e−03, P = 0.043) and P3 and P4 (β = − 2.31e−03, P = 0.011); alpha diversity, zonulin calprotectin and calprotectin change were rank transformed, repeated measures and correlation trend lines are coloured by individual child. PCo1 and PCo2 scores were treated here as a dimensionality-reduced measure of sample composition relative to whole-dataset variabilityBack to article page